Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Let’s do something amazing together! We’re seeking a dynamic and experienced General Manager, Europe (EU Region) to lead the build-out and execution of our European commercial and operational strategy. This role will be responsible for establishing and leading a high-performing, cross-functional regional organization and driving successful product launches across key European markets.
The General Manager will initially focus on priority markets including Germany, France, Italy, Spain, and the United Kingdom, with responsibility for expanding Arrowhead’s presence across the broader EU Region over time.
This leader will serve as the senior-most executive in Europe and a key member of the global leadership team, ensuring alignment between regional execution and global strategy.
Responsibilities
Strategic Leadership
- Execute Arrowhead’s European strategy, including commercialization, market access, scientific excellence, and organizational build-out.
- Align regional strategies with global priorities while tailoring execution to local market dynamics.
Commercialization And Market Launch
- Drive launch planning and execution across initial priority markets (DE, FR, IT, ES, UK).
- Drive pricing, reimbursement, and market access strategies in collaboration with global and local stakeholders, including with key external advisors/partners.
- Ensure strong adoption and performance of Arrowhead’s therapies post-launch.
Cross-Functional Leadership
- Build, lead, and inspire a high-performing regional cross-functional leadership team.
- Foster a culture of accountability, collaboration, and patient-centricity.
- Ensure effective coordination across country teams, global headquarters, and external advisors/partners.
External Engagement
- Serve as Arrowhead’s senior representative across Europe with key external stakeholders, including regulators, payers, healthcare providers, and partners.
- Build strategic relationships to support access, adoption, and long-term growth.
Operational Excellence
- Establish scalable infrastructure, processes, and compliance frameworks aligned with European regulations.
- Oversee regional P&L, resource allocation, and performance management.
- Ensure adherence to all legal, regulatory, and corporate governance requirements.
Requirements
Experience
- 20+ years of experience in the biopharmaceutical industry, including significant leadership roles in Europe.
- Proven track record of leading successful product launches in major European markets.
- Deep understanding of European market access, pricing, and reimbursement systems.
- Experience building and scaling regional and/or country organizations.
Leadership
- Demonstrated ability to independently lead complex, cross-functional teams in a matrixed, global environment with autonomy .
- Strong strategic mindset paired with operational execution capabilities.
- Experience managing senior leaders and influencing at the executive level.
Expertise
- Strong knowledge of the European healthcare landscape, including regulatory pathways and payer systems.
- Experience in rare disease, specialty, or innovative therapeutics (RNAi or similar modalities a plus).
- Experience in cardiometabolic therapeutic areas, preferably with a focus on dyslipidemias.
Physical other requirements
- Based in Europe. Strong preference for this role to be based from Switzerland, may consider: Netherlands, Germany, UK.
- Willingness and ability to travel as needed domestically and internationally.
Preferred
- Advanced degree (MBA, PhD, MD, or equivalent)
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
California Applicant Privacy Policy